Postoperative respiratory depression Acute respiratory failure

Postoperative respiratory depression: IV injection 1–1.5 mg/kg repeated at hourly intervals, or

2–3 mg/minute, adjusted according to response. Acute respiratory failure: 1.5–4 mg/minute as an

, adjusted according to response

Molecular weight :433

%Protein binding :No data

%Excreted unchanged in urine : <5

Volume of distribution (L/kg) :0.58–2.74

half-life – normal/ESRD (hrs) :2.4–4.1/–

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function

CAPD :Unknown dialysability. Dose as in normal renal function

HD :Unknown dialysability. Dose as in normal renal function

HDF/high flux :Unknown dialysability. Dose as in normal renal function

CAV/VVHD :Unknown dialysability. Dose as in normal renal function

Potentially hazardous interactions with other drugs

None known

–

IV bolus,

IV injection: over at least 30 seconds

as indication

Doxapram has a narrow margin of safety; the minimum effective dosage should be used and maximum recommended dosages should not be exceeded

Unlike naloxone, doxapram does not reverse the other effects of opioid analgesics